This will include specific blood tests, and possibly an ultrasound. Based on these results, further work-up is required. Loss of hair, blackheads, darkening of skin, and hard scaly patches on the skin, especially the elbows, etc.įirstly, a full physical exam, basic blood tests and a urinalysis will be conducted. Increased panting, even in cool conditions The most common clinical signs associated with Cushing's Disease are:ĭrinking and urinat ing more, including toileting accidents Growth of the pituitary tumour would give the patient a less favourable prognosis. However, many dogs with this form of Cushing's Disease can live normal lives for many years as long as they take their medication and stay under close medical supervision. Unfortunately, this is sometimes not the case.
Generally, if the activity of the adrenal gland can be controlled, the dog will live a relatively normal life. Depending on the size of the tumour, the presence of signs other than Cushing's will be variable. The tumour may be microscopic or quite large. Excessive cortisol secretion is the result. The tumour causes the pituitary to overproduce a hormone which stimulates the adrenal glands. The most common cause of Cushing's Disease (85% of all cases) is a tumour of the pituitary gland. Cushing's Disease may be the result of a benign or malignant tumour of the adrenal gland. Occasionally the use of ointment containing cortisone or its derivatives over a long period of time can result in excessive intake due to absorption through the skin or eyes or by the dog licking the product. Although the injections or tablets were given for a legitimate medical reason, their excess is now detrimental. This may occur from oral or injectable medications over a long period. Iatrogenic Cushing's Disease means that the excess of cortisone has resulted from excessive administration of synthetic cortisones. Regardless of the cause, the clinical signs are essentially the same. There are three mechanisms by which this disease can occur. The most widely known of these substances is cortisol (also known as cortisone), which helps to control the immune system and stress responses. The adrenal glands produce several vital substances that regulate a variety of body functions and are necessary to sustain life. The correct medical term for this disease is hyperadrenocorticism. Simply, Cushing's Disease is a disease in which the adrenal glands overproduce certain hormones.
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